The mechanism of DNA unwinding tract formation and regulation of directionality during DNA mismatch repair

Recruitment for this position has closed.

PhD project: This project will address the molecular mechanisms by which the DNA mismatch repair system is able to remove incorrectly incorporated nucleotides from newly replicated DNA, in particular during the step following mismatch recognition and strand identification, when the DNA is being unwound and degraded by a helicase and exonucleases. You will study this unwinding tract formation using different approaches, specifically to identify determinants of tract length formation and the mechanism by which directionality is achieved. You will be trained in protein purification and characterization, single molecule imaging (scanning/atomic force microscopy) and in vitro DNA repair assays to study the coordinated enzyme activities during DNA mismatch repair.

This project will be hosted at Erasmus MC (Rotterdam, the Netherlands), with long and short training visits to other consortium partners.

Qualifications and skills

We are looking for an enthusiastic candidate with a MSc in Biochemistry, Structural Biology or closely related field, good command of English (IELTS grade min. 6.5, or equivalent). We welcome applicants of all nationalities. Being able to present a certificate of good conduct is a condition for the appointment.

Terms of employment

You will receive a temporary position for 4 years. The gross monthly salary is €2244,- in the 1st year and increases to € 2874,- in the 4th year (scale OIO). The terms of employment are according to the Collective Bargaining Agreement for Dutch University Medical Centers (CAO UMC). Additionally, employment terms for Marie Curie projects ( apply for the first three years of employment.

Contact information

For more information about this position, please contact Dr.Ir. Joyce Lebbink (

Eligibility criteria and instructions on how to apply are listed on our vacancies page.
Application deadline for this position is Monday April 3rd, 2017.